Institute of Physiology II – Publications

Selected Publications

1. Martin-Belmonte M, Aguado C, Alfaro-Ruiz R, Kulik A, de la Ossa L, Moreno-Martinez AE, Alberquilla S, Garcia-Carracedo L, Fernandez M, Fajardo-Serrano A, Aso E, Shigemoto R, Martin ED, Fukazawa Y, Ciruela F, Lujan R (2024) Nanoarchitecture of Ca_v2.1 channels and GABA_B receptors in the mouse hippocampus: Impact of APP/PS1 pathology. Brain Pathology 17:e13279.
2. Kaufhold, D, Maristany de Las Casas E, Ocana -Fernandez MDA, Cazala A, Yuan M, Kulik A, Cholvin T, Steup S, Sauer JF, Eyre MD, Elgueta C, Strüber M, Bartos M (2024) Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience. Cell rep 43:113806.
3. Grigoryan G, Harada H, Knobloch-Bollmann HS, Kilias A, Kaufhold D, Kulik A, Eyre MD, Bartos M (2023) Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory. Proc Natl Acad Sci USA 120, e2312752120.
4. Bhandari P, Vandael D, Fernandez-Fernandez D, Fritzius T, Kleindienst D, Önal C, Montanaro J, Gassmann M, Jonas P, Kulik A, Bettler B, Shigemoto R, Koppensteiner P (2021) GABA_B receptor auxiliary subunits modulate Ca_v2.3-mediated release from medial habenula terminals. eLife 9:e68274.
5. Booker SA, Harada H, Elgueta C, Bank J, Bartos M, Kulik A*, Vida I* (2020) Presynaptic GABA_B receptors functionally uncouple somatostatin interneurons from the active hippocampal network. eLife 9: e51156.
6. Schwenk J, Boudkkazi S, Kocylowski M, Brechet A, Zolles G, Bus T, Costa K, Bildl W, Sprengel R, Kulik A, Roeper J, Schulte U, Fakler B (2019) ER assembly line of AMPA-receptors controls excitatory neurotransmission and its plasticity. Neuron 104:680-692.
7. Booker SA, Loreth D, Gee AL, Watanbe M, Kind PC, Wyllie DJA, Kulik A*, Vida I* (2018) Postsynaptic GABA_BRs inhibit L-type calcium channels and abolish long-term potentiation in hippocampal somatostatin interneurons. Cell Rep 22:36-43.
8. Kulik A, Booker SA, Vida I (2018) Differential distribution and function of GABA_BRs in somato-dendritic and axonal compartments of principal cells and interneurons in cortical circuits. Neuropharmacology 136:80-91.
9. Nieto-Rostro M, Ramgoolam K, Pratt WS, Kulik A, Dolphin AC (2018) Visualizing endogenous N-type calcium channels in the pain pathway in vivo: a₂d1 ablation abolishes their cell surface trafficking. Proc Natl Acad Sci USA 115:12043-12052.
10. Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, Varro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I*, Kulik A* (2017) KCTD12 auxiliary proteins modulate kinetics of GABA_B receptor-mediated inhibition in cholecystokinin-containing interneurons. Cereb Cortex 27:2318-2334.
11. Sibbe M, Kulik A (2017) GABAergic regulation of adult hippocampal neurogenesis. Mol Neurobiol 54:5497-5510.
12. Althof D, Baehrens D, Watanabe M, Suzuki N, Fakler B, Kulik A (2015) Inhibitory and excitatory axon terminals share a common nano-architecture of their Ca_v2.1 (P/Q-type) Ca²⁺ channels. Front Cell Neurosci 9:315.
13. Hainmüller T, Krieglstein K, Kulik A, Bartos M (2014) Joint CP-AMPA and group I mGlu receptor activation is required for synaptic plasticity in dentate gyrus fast spiking interneurons. Proc Natl Acad Sci USA 111:13211-13216.
14. Booker SA, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik A*, Vida I* (2013) Differential GABA_B receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. J Neurosci 33:7961-7974.
15. Parajuli LK, Nakajima C, Kulik A*, Matsui K, Schneider T, Shigemoto R, Fukazawa Y* (2012) Quantitative regional and ultrastructural localization of the Ca_v2.3 subunit of R-type calcium channel in mouse brain. J Neurosci 32:13555-13567.
16. Holderith N, Lorincz A, Katona G, Rozsa B, Kulik A, Watanabe M, Nusser Z (2012) Release probability of hippocampal glutamatergic terminals scales with the size of the active zone. Nat Neurosci 15:988-997.
17. Guetg N, Seddik R, Vigot R, Turecek R, Gassmann M, Vogt KE, Bräuner-Osborne H, Shigemoto R, Kretz O, Frotscher M, Kulik A*, Bettler B* (2009) The GABA_B1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. J Neurosci 29:1414-1423.
18. Bucurenciu I, Kulik A, Schwaller B, Frotscher M, Jonas P (2008) Nanodomain coupling between Ca²⁺ channels and Ca²⁺ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse. Neuron 57:536-545.
19. Kulik A, Vida I, Fukazawa Y, Guetg N, Kasugai Y, Marker C, Rigato F, Bettler B, Wickman K, Frotscher M, Shigemoto R (2006) Compartment-dependent colocalization of Kir3.2-containing K⁺ channels and GABA_B receptors in hippocampal pyramidal cells. J Neurosci 26:4289-4297.
20. Kulik A, Nakadate K, Hagiwara A, Fukazawa Y, Lujan R, Saito H, Suzuki N, Futatsugi A, Mikoshiba K, Frotscher M, Shigemoto R (2004) Immunocytochemical localization of the a_1A subunit of the P/Q-type calcium channel in the rat cerebellum. Eur J Neurosci 19:2169-2178.
21. Kulik A, Vida I, Lujan R, Haas CA, Lopez-Bendito G, Shigemoto R, Frotscher M (2003) Subcellular localization of metabotropic GABA_B receptor subunits GABA_B1a/b and GABA_B2 in the rat hippocampus. J Neurosci 23:11026-11035.

* corresponding authors

Research Grants

2008-2012 German Research Foundation (DFG, SFB-780): ‘Role of metabotropic receptors and their effector Kir3 channels in synaptic transmission’. A. Kulik.

2012-2014 BIOSS Centre for Biological Signalling Studies Project Package (BIOSS-2): ‘Quantitative analysis of axonal Ca²⁺ channels in cortical GABAergic neurons’. A. Kulik.

2015-2017 German Research Foundation (DFG, Research Unit (FOR 2143): ‘Subcellular distribution and dynamics of glutamate receptors and Ca_v channels in interneuron plasticity’. A. Kulik.

2015-2018 BIOSS Centre for Biological Signalling Studies Project Package (BIOSS-2): ‘Nano-scale organization and dynamics of presynaptic Ca²⁺ channels’. A. Kulik.

2018-2021 German Research Foundation (DFG, Research Unit (FOR 2143): ‘Subcellular distribution and dynamics of neurotransmitter receptors and Ca_v channels in interneuron plasticity’. A. Kulik.

2024-2027 German Research Foundation (DFG, CRC/TRR 384): ‘Dendritic mechanisms underlying a sparse spatial code in the dentate gyrus’. C. Elgueta, A. Kulik.

2024-2027 German Research Foundation (DFG, CRC/TRR 384): ‘Light and electron microscopic imaging and morphometric analysis of inhibitory neuronal circuits and signaling proteins’. A. Kulik, I. Vida.