Clinic for Neurology and Neurophysiology

General
Team
External Website

General Information

Clinic for Neurology and Neurophysiology
University Hospital
Breisacher Str. 64
79106 Freiburg
Germany

How to get there

By train

The Bundesbahn arrives in an hourly direct connection by IC / ICE at Freiburg main station. Coming from Kaiserstuhl get off at the DB stop Universitätsklinikum. Take the tram line 4 from the main station and get off at the Kilianstraße stop.

By car

There is only limited parking space available. Please use park-and-ride areas and public transport. Take motorway A5 and exit Freiburg-Mitte, follow the signs “Universitätsklinikum”. Coming from the Black Forest on the B31 federal road, in Freiburg follow the signs for “Universitätsklinikum”.

By airplane

The nearest airplane destination is EuroAirport Basel-Mulhouse-Freiburg. Take the bus from there to Freiburg main station. Then take the tram line 4 from the main station and get off at the Kilianstraße stop.

Aggregation and accumulation of proteins in the brain are common features of diverse age-related neurodegenerative diseases. Each of these neurodegenerative diseases is associated with abnormalities in the folding of a different protein leading to protein aggregation and ultimately to neuronal death. Alzheimers Disease (AD) is one of these protein conformational diseases which is characterized by the extracellular accumulation of amyloid-? peptide and neuroanatomical changes. Kinetic studies have shown that A? protein aggregation occur via a nucleation mechanism, which resembles a crystallization process (Figure 1). However, little is known about how protein aggregation and deposition is initiated in vivo.